期刊简介
本刊是医学综合类学术期刊，逢双月26日出版，主要刊登我校科技人员及校友在基础医学、预防医学、药学、临床医学等方面的科研成果及经验报告和综述等。
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首页>山西医科大学学报杂志
- 杂志名称：山西医科大学学报杂志
- 主管单位：山西省教育厅
- 主办单位：山西医科大学
- 国际刊号：1007-6611
- 国内刊号：14-1216/R
- 出版周期：月刊
期刊荣誉：中国科技类核心期刊 中国科技论文统计源期刊期刊收录：知网收录(中), CA 化学文摘(美), 万方收录(中), 上海图书馆馆藏, 国家图书馆馆藏, 统计源核心期刊(中国科技论文核心期刊), Pж(AJ) 文摘杂志(俄), 维普收录(中)
前额叶皮层的5-HT谷氨酸:一个新的抗精神病药的靶点
张策
关键词：血清素, 谷氨酸盐类, 额叶前皮质, 安定药, 强
摘要：Activation of neocortical 5 hydroxytryptamine 2A (5-HT2A) re ceptors is thought to mediate the profoud psychominetic effects of hallucinogeni c drugs such as lysergic acid diethylamide(LSD).Coversely, blockade of neocortic al 5-HT2A receptor may be related to the thymoleptic effects of newly rele ased antidepressant especially atypical antipsychotic drugs. Electrophsiological experiments using in vitro rat slices of the medial prefrontal cortex has f ound that activation of 5-HT2A receptors results in glutamate release fr om thalamocortical terminals.In addition to activation of 5-HT2A receptors , metabotropic glutamate (mGluR),and neuropeptide (μ-opioid) receptors suppress this release of glutamate that is induced by 5-HT2A receptor activation. Recent clinical reports have found clear structural change in the prefrontal cor tex of depressed patients. Furthermore, a number of post-mortem studies of suici des from different laboratories have found an increased number of 5-HT2A b inding sites in certain regions of the prefrontal cortex. Thus,understanding the effects of 5-HT2A receptor activation in prefrontal cortex is likely to b e relevant for the development of antidepressant drugs.
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